BRI1 is a critical component of a plasma-membrane receptor for plant steroids

@article{Wang2001BRI1IA,
  title={BRI1 is a critical component of a plasma-membrane receptor for plant steroids},
  author={Zhi-Yong Wang and Hideharu Seto and Shozo Fujioka and Shigeo Yoshida and Joanne Chory},
  journal={Nature},
  year={2001},
  volume={410},
  pages={380-383}
}
Most multicellular organisms use steroids as signalling molecules for physiological and developmental regulation. Two different modes of steroid action have been described in animal systems: the well-studied gene regulation response mediated by nuclear receptors, and the rapid non-genomic responses mediated by proposed membrane-bound receptors. Plant genomes do not seem to encode members of the nuclear receptor superfamily. However, a transmembrane receptor kinase, brassinosteroid-insensitive1… 
Binding of brassinosteroids to the extracellular domain of plant receptor kinase BRI1
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Brassinosteroids (BRs) are structurally similar to the animal steroid hormones found in vertebrates and insects, and Plants also use steroids as signaling molecules.
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TLDR
Crystal structures reveal why the brassinosteroid receptor kinase requires another kinase helper protein for activation and reveal how known missense mutations in BRI1 and in SERKs modulate brass inosteroid signaling and the targeting mechanism of B RI1 receptor antagonists.
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TLDR
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Ligand perception, activation, and early signaling of plant steroid receptor brassinosteroid insensitive 1.
TLDR
This review will focus on the recent advances on the mechanism of BRI1 phosphorylation and activation, the regulation of its receptor complex, the structure basis of B RI1 ectodomain and BR recognition, its direct substrates, and the termination of the activated BRI2 receptor complex.
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TLDR
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Regulation of Three Key Kinases of Brassinosteroid Signaling Pathway
TLDR
A critical analysis of the current literature concerning activation, inactivation, and other regulatory mechanisms of three key kinases of the BR signaling cascade, BRI1, BAK1, and BIN2 is provided, and some unresolved controversies and outstanding questions that require further investigation are discussed.
Brassinosteroid Signaling Pathway
TLDR
The emerging picture of BR signal transduction diverges radically from the paradigms of animal steroid signaling, which generally involve the action of members of the nuclear receptor superfamily.
Membrane steroid-binding protein 1 (MSBP1) negatively regulates brassinosteroid signaling by enhancing the endocytosis of BAK1
TLDR
It is shown that enhanced MSBP1 expression reduces the interaction between BRI1 and BAK1 in vivo, demonstrating that MS BP1 acts as a negative factor at an early step of the BR signaling pathway.
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