BRG1 promotes survival of UV-irradiated melanoma cells by cooperating with MITF to activate the melanoma inhibitor of apoptosis gene

@inproceedings{Saladi2013BRG1PS,
  title={BRG1 promotes survival of UV-irradiated melanoma cells by cooperating with MITF to activate the melanoma inhibitor of apoptosis gene},
  author={Srinivas Vinod Saladi and Philip G. Wong and Archit R. Trivedi and Himangi G. Marathe and Bridget Keenen and Shweta Aras and Zi-Qi Liew and Vijayasaradhi Setaluri and Ivana L de la Serna},
  booktitle={Pigment cell & melanoma research},
  year={2013}
}
Microphthalmia-associated transcription factor (MITF) is a survival factor in melanocytes and melanoma cells. MITF regulates expression of antiapoptotic genes and promotes lineage-specific survival in response to ultraviolet (UV) radiation and to chemotherapeutics. SWI/SNF chromatin-remodeling enzymes interact with MITF to regulate MITF target gene expression. We determined that the catalytic subunit, BRG1, of the SWI/SNF complex protects melanoma cells against UV-induced death. BRG1 prevents… CONTINUE READING
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