• Biology, Medicine
• Published in Cell cycle 2011
• DOI:10.4161/cc.10.15.16312

BRCT domains: easy as one, two, three.

@article{Leung2011BRCTDE,
  title={BRCT domains: easy as one, two, three.},
  author={Charles Chung Yun Leung and J N Mark Glover},
  journal={Cell cycle},
  year={2011},
  volume={10 15},
  pages={
          2461-70
        }
}

• Charles Chung Yun Leung, J N Mark Glover

BRCA1 C-terminal (BRCT) domains are integral signaling modules in the DNA damage response (DDR). Aside from their established roles as phospho-peptide binding modules, BRCT domains have been implicated in phosphorylation-independent protein interactions, DNA binding and poly(ADP-ribose) (PAR) binding. These numerous functions can be attributed to the diversity in BRCT domain structure and architecture, where domains can exist as isolated single domains or assemble into higher order homo- or… CONTINUE READING

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