BRCC2 inhibits breast cancer cell growth and metastasis in vitro and in vivo via downregulating AKT pathway


In our previous study, we demonstrated that the BRCC2 (breast cancer cell 2) gene is a proapoptotic molecule that interacts with Bcl-XL. BRCC2 downregulation is associated with poor disease-free and overall survival in breast cancer. In this study, we aimed to investigate the role of BRCC2 in tumor suppression in breast cancer. In clinical breast cancer… (More)
DOI: 10.1038/cddis.2013.290


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