BRCA2 is required for neurogenesis and suppression of medulloblastoma.

@article{Frappart2007BRCA2IR,
  title={BRCA2 is required for neurogenesis and suppression of medulloblastoma.},
  author={Pierre-Olivier Frappart and Youngsoo Lee and Jayne M Lamont and Peter J Mckinnon},
  journal={The EMBO journal},
  year={2007},
  volume={26 11},
  pages={
          2732-42
        }
}
Defective DNA damage responses in the nervous system can result in neurodegeneration or tumorigenesis. Despite the importance of DNA damage signalling, the neural function of many critical DNA repair factors is unclear. BRCA2 is necessary for homologous recombination repair of DNA and the prevention of diseases including Fanconi Anemia and cancer. We determined the role of BRCA2 during brain development by inactivating murine Brca2 throughout neural tissues. In striking contrast to early… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 59 CITATIONS, ESTIMATED 55% COVERAGE

BCCIP suppresses tumor initiation but is required for tumor progression.

  • Cancer research
  • 2013
VIEW 5 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Tumor and Stem Cell

VIEW 5 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2014
VIEW 4 EXCERPTS
CITES METHODS

FILTER CITATIONS BY YEAR

2006
2018

CITATION STATISTICS

  • 8 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 75 REFERENCES

Emerging functions of BRCA2 in DNA recombination.

  • Trends in biochemical sciences
  • 2004
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Molecular views of recombination proteins and their control

  • Nature Reviews Molecular Cell Biology
  • 2003
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL