BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications.

@article{Goggins2000BRCA2II,
  title={BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications.},
  author={Michael G. Goggins and Ralph H. Hruban and Scott E. Kern},
  journal={The American journal of pathology},
  year={2000},
  volume={156 5},
  pages={1767-71}
}
Patients harboring germline BRCA2 mutations are at an increased risk of developing pancreatic cancer. We investigated the prevalence of biallelic inactivation of BRCA2 in the presumed precursors to invasive pancreatic ductal carcinomas, pancreatic intraepithelial neoplasia (PanIN). Surgical resection specimens from three patients with germline BRCA2 mutations who developed pancreatic ductal adenocarcinoma were studied. Fourteen PanINs were needle-microdissected from paraffin-embedded tissue… CONTINUE READING

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