BRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients

@inproceedings{KoteJarai2011BRCA2IA,
  title={BRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients},
  author={Zsofia Kote-Jarai and Daniel A. Leongamornlert and Edward J. Saunders and Malgorzata Tymrakiewicz and Elena Castro and Nadiya Mahmud and Michelle Guy and Stephen M Edwards and Lynne T O'Brien and Emma J. Sawyer and Amanda L Hall and Rosemary A. Wilkinson and Tokhir Dadaev and Chee Leong Goh and Douglas T. Easton and D E Goldgar and Rosalind A. Eeles},
  booktitle={British Journal of Cancer},
  year={2011}
}
Background:A family history of prostate cancer (PrCa) is a strong risk factor for the disease, indicating that inherited factors are important in this disease. We previously estimated that about 2% of PrCa cases diagnosed ⩽55 years harbour a BRCA2 mutation and PrCa among BRCA2 carriers has been shown to be more aggressive, with poorer survival.Methods:To further evaluate the role of BRCA2 in PrCa predisposition, we screened 1864 men with PrCa aged between 36 and 88 years. We analysed the BRCA2… CONTINUE READING
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