BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells

Abstract

Genome maintenance by homologous recombination depends on coordinating many proteins in time and space to assemble at DNA break sites. To understand this process, we followed the mobility of BRCA2, a critical recombination mediator, in live cells at the single-molecule level using both single-particle tracking and fluorescence correlation spectroscopy… (More)
DOI: 10.1083/jcb.201405014

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