BRCA2-dependent and independent formation of RAD51 nuclear foci

Abstract

The formation of RAD51 foci in response to ionizing radiation (IR) represents an important step in the repair of DNA double-strand breaks. RAD51 foci also appear during S phase and are thought to be required for the restart of stalled or broken replication forks. The RAD51 recombinase interacts directly with the breast cancer-associated tumour suppressor… (More)
DOI: 10.1038/sj.onc.1206263

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