BRCA2 and homologous recombination

  title={BRCA2 and homologous recombination},
  author={Brian J Orelli and Douglas K. Bishop},
  journal={Breast Cancer Research : BCR},
  pages={294 - 298}
Two recent papers provide new evidence relevant to the role of the breast cancer susceptibility gene BRCA2 in DNA repair. Moynahan et al provide genetic data indicating a requirement for BRCA2 in homology-dependent (recombinational) repair of DNA double-strand breaks. The second paper, by Davies et al, begins to address the mechanism through which BRCA2 makes its contribution to recombinational repair. BRCA2 appears to function in recombination via interactions with the major eukaryotic… CONTINUE READING


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