BRCA2 Coordinates the Activities of Cell-Cycle Kinases to Promote Genome Stability

@inproceedings{Yata2014BRCA2CT,
  title={BRCA2 Coordinates the Activities of Cell-Cycle Kinases to Promote Genome Stability},
  author={Keiko Yata and Jean-Yves Bleuyard and Ryuichiro Nakato and Christine Ralf and Yuki Katou and Rebekka A.V. Schwab and Wojciech Niedzwiedz and Katsuhiko Shirahige and Fumiko Esashi},
  booktitle={Cell reports},
  year={2014}
}
Numerous human genome instability syndromes, including cancer, are closely associated with events arising from malfunction of the essential recombinase Rad51. However, little is known about how Rad51 is dynamically regulated in human cells. Here, we show that the breast cancer susceptibility protein BRCA2, a key Rad51 binding partner, coordinates the activity of the central cell-cycle drivers CDKs and Plk1 to promote Rad51-mediated genome stability control. The soluble nuclear fraction of BRCA2… CONTINUE READING
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