BRCA1a has antitumor activity in TN breast, ovarian and prostate cancers

@article{Yuli2007BRCA1aHA,
  title={BRCA1a has antitumor activity in TN breast, ovarian and prostate cancers},
  author={Chen Yuli and Ningsheng Shao and Roshni Rao and P Aysola and V Reddy and G Oprea-llies and L Lee and Joel A Okoli and Emily A. Partridge and E. Shyam P. Reddy and V. Nageswar Rao},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={6031-6037}
}
Breast cancer gene 1 (BRCA1) mutations predispose women to breast and ovarian cancers and men to increased risks for prostate cancer. We have previously showed BRCA1 splice variant BRCA1a/p110 to induce apoptosis of human breast cancer cells. In the current study, stable expression of BRCA1a/p110 resulted in inhibition of growth of estrogen receptor (ER)-positive and triple-negative (TN) human breast, ovarian, prostate and colon cancer cells and mouse fibroblast cells. Similar to wild-type… CONTINUE READING

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