BRCA1 und BRCA2: Mutationen und andere genetische Veränderungen – praktische Relevanz

Abstract

Genetic predisposition is responsible for 5–10 % of all breast cancer. Within the past 10 years the major susceptibility genes for breast cancer, BRCA1 and BRCA2, have been identified. Both genes are considered to be tumor-suppressor genes, but their function is poorly understood. Current genetic testing for mutated BRCA1 and BRCA2 is the basis for… (More)
DOI: 10.1007/s001040050659

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