BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity.

@article{Shakya2011BRCA1TS,
  title={BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity.},
  author={Reena Shakya and Latarsha J Reid and Colleen R. Reczek and Francesca Cole and Dieter Egli and Chyuan-Sheng Lin and Dirk G deRooij and Steffen Hirsch and Kandasamy Ravi and J. Braxton Hicks and Matthias Szabolcs and Maria Jasin and Richard D. Baer and Thomas Claus Ludwig},
  journal={Science},
  year={2011},
  volume={334 6055},
  pages={
          525-8
        }
}
Germline mutations of the breast cancer 1 (BRCA1) gene are a major cause of familial breast and ovarian cancer. The BRCA1 protein displays E3 ubiquitin ligase activity, and this enzymatic function is thought to be required for tumor suppression. To test this hypothesis, we generated mice that express an enzymatically defective Brca1. We found that this mutant Brca1 prevents tumor formation to the same degree as does wild-type Brca1 in three different genetically engineered mouse (GEM) models of… CONTINUE READING

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