BRCA1-related gene signature in breast cancer: the role of ER status and molecular type.

@article{Lisowska2011BRCA1relatedGS,
  title={BRCA1-related gene signature in breast cancer: the role of ER status and molecular type.},
  author={Katarzyna M Lisowska and Volha Dudaladava and Michał Jarząb and Tomasz Huzarski and Ewa Chmielik and Ewa Stobiecka and Jan A. Lubiński and Barbara Jarzab},
  journal={Frontiers in bioscience},
  year={2011},
  volume={3},
  pages={125-36}
}
There is an ongoing debate whether hereditary breast cancer is a clinical entity distinct from sporadic breast cancer. We tried to shed some light on this issue by comparing the molecular profiles of these two types of cancer using DNA microarrays. Our results show that a previously reported marked difference between BRCA1-mutation linked and sporadic breast cancer was probably due to uneven stratification of samples with different ER status and basal-like versus luminal-like subtype. We… CONTINUE READING