BRCA1 promoter methylation predicts adverse ovarian cancer prognosis.

  title={BRCA1 promoter methylation predicts adverse ovarian cancer prognosis.},
  author={Jing Wang Chiang and Beth Y. Karlan and Llana Cass and Rae Lynn Baldwin},
  journal={Gynecologic oncology},
  volume={101 3},
OBJECTIVE To compare the clinical outcome of ovarian cancer patients whose tumors contain BRCA1 genes silenced by promoter hypermethylation to patients with germline BRCA1 mutations and to patients with wild-type BRCA genes. METHODS Ovarian cancers from a hospital-based tumor bank were characterized as having a BRCA1 mutation; or a methylated BRCA1, BRCA1 pseudogene or MLH1 promotor; or a wild-type BRCA gene. Survival of patients with methylated BRCA1 promoters (N = 11) was compared to that… CONTINUE READING

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