BRCA1 pathway function in basal-like breast cancer cells.

  title={BRCA1 pathway function in basal-like breast cancer cells.},
  author={Sarah J. Hill and Allison P. Clark and Daniel P. Silver and David M. Livingston},
  journal={Molecular and cellular biology},
  volume={34 20},
Sporadic basal-like cancers (BLCs) are a common subtype of breast cancer that share multiple biological properties with BRCA1-mutated breast tumors. Despite being BRCA1(+/+), sporadic BLCs are widely viewed as phenocopies of BRCA1-mutated breast cancers, because they are hypothesized to manifest a BRCA1 functional defect or breakdown of a pathway(s) in which BRCA1 plays a major role. The role of BRCA1 in the repair of double-strand DNA breaks by homologous recombination (HR) is its best… CONTINUE READING
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