BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells.

@article{Lu2006BRCA1NR,
  title={BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells.},
  author={Meiling Lu and Dong Chen and Zhihong Lin and Scott Reierstad and Amy M Trauernicht and Thomas G. Boyer and Serdar E. Bulun},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2006},
  volume={91 11},
  pages={4514-9}
}
CONTEXT Heterozygous mutations of the breast cancer susceptibility gene 1 (BRCA1) gene that lead to haploinsufficiency increase the risk of breast cancer. The underlying mechanism is unknown. OBJECTIVE Because excessive estrogen production increases the risk of breast cancer, we determined whether BRCA1 suppresses aromatase expression and thus local estrogen production in breast adipose fibroblasts (BAFs) and breast malignant epithelial cells by interacting with the cancer-associated promoter… CONTINUE READING

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