BRCA1 mutations in a population-based sample of young women with breast cancer.

@article{Langston1996BRCA1MI,
  title={BRCA1 mutations in a population-based sample of young women with breast cancer.},
  author={Amelia A. Langston and Kathleen E. Malone and John M D Thompson and Janet R. Daling and Elaine A Ostrander},
  journal={The New England journal of medicine},
  year={1996},
  volume={334 3},
  pages={137-42}
}
BACKGROUND Inherited mutations in the BRCA1 gene are associated with a high risk of breast and ovarian cancer in some families. However, little is known about the contribution of BRCA1 mutations to breast cancer in the general population. We analyzed DNA samples from women enrolled in a population-based study of early-onset breast cancer to assess the spectrum and frequency of germ-line BRCA1 mutations in young women with breast cancer. METHODS We studied 80 women in whom breast cancer was… CONTINUE READING

From This Paper

Topics from this paper.
110 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 110 extracted citations

Similar Papers

Loading similar papers…