BRCA1 mutations and breast cancer in the general population: analyses in women before age 35 years and in women before age 45 years with first-degree family history.

@article{Malone1998BRCA1MA,
  title={BRCA1 mutations and breast cancer in the general population: analyses in women before age 35 years and in women before age 45 years with first-degree family history.},
  author={Kathleen E. Malone and Janet R. Daling and John M D Thompson and Cecilia A O'Brien and Leigh V Francisco and Elaine A Ostrander},
  journal={JAMA},
  year={1998},
  volume={279 12},
  pages={922-9}
}
CONTEXT Studies of high-risk families with multiple early-onset cases of breast cancer have been useful for assessing the type and spectrum of germline mutations on the BRCA1 gene, but do not provide guidance to women with modest family history profiles. Thus, studies of women from the general population are needed to determine the BRCA1 mutation frequency in women perceived to be at high risk, and to develop profiles of those most likely to be carriers. OBJECTIVE To characterize frequency… CONTINUE READING