BRCA1 mRNA expression levels predict for overall survival in ovarian cancer after chemotherapy.

@article{Quinn2007BRCA1ME,
  title={BRCA1 mRNA expression levels predict for overall survival in ovarian cancer after chemotherapy.},
  author={Jennifer E. Quinn and Colin R. James and G Edward Stewart and Jude Marie Mulligan and Patricia H White and Gary K F Chang and Paul Mullan and Patrick Gerard Johnston and Richard J. Wilson and Denis Paul Harkin},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 24},
  pages={7413-20}
}
PURPOSE We investigated whether BRCA1 mRNA expression levels may represent a biomarker of survival in sporadic epithelial ovarian cancer following chemotherapy treatment. EXPERIMENTAL DESIGN The effect of loss of BRCA1 expression on chemotherapy response in ovarian cancer was measured in vitro using dose inhibition assays and Annexin V flow cytometry. Univariate and multivariate analyses were done to evaluate the relationship between BRCA1 mRNA expression levels and survival after… CONTINUE READING