BRCA1 loss preexisting in small subpopulations of prostate cancer is associated with advanced disease and metastatic spread to lymph nodes and peripheral blood.

@article{Bednarz2010BRCA1LP,
  title={BRCA1 loss preexisting in small subpopulations of prostate cancer is associated with advanced disease and metastatic spread to lymph nodes and peripheral blood.},
  author={Natalia Bednarz and Elke Eltze and Axel Semjonow and Michael Rink and Antje Andreas and Lennart Mulder and Juliane Hannemann and Margit Fisch and Klaus Pantel and Heinz-ulrich G. Weier and Krzysztof Bielawski and Burkhard Brandt},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 13},
  pages={3340-8}
}
PURPOSE A preliminary study performed on a small cohort of multifocal prostate cancer (PCa) detected BRCA1 allelic imbalances among circulating tumor cells (CTC). The present analysis was aimed to elucidate the biological and clinical roles of BRCA1 losses in metastatic spread and tumor progression in PCa patients. EXPERIMENTAL DESIGN To map molecular progression in PCa outgrowth, we used fluorescence in situ hybridization analysis of primary tumors and lymph node sections, and CTCs from… CONTINUE READING

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