BRCA1 is required for postreplication repair after UV-induced DNA damage.

@article{Pathania2011BRCA1IR,
  title={BRCA1 is required for postreplication repair after UV-induced DNA damage.},
  author={Shailja Pathania and Jenna Nguyen and Sarah J. Hill and Ralph Scully and Guillaume O. Adelmant and Jarrod A. Marto and J. Le Feunteun and D. Michelson Livingston},
  journal={Molecular cell},
  year={2011},
  volume={44 2},
  pages={
          235-51
        }
}
BRCA1 contributes to the response to UV irradiation. Utilizing its BRCT motifs, it is recruited during S/G2 to UV-damaged sites in a DNA replication-dependent but nucleotide excision repair (NER)-independent manner. More specifically, at UV-stalled replication forks, it promotes photoproduct excision, suppression of translesion synthesis, and the localization and activation of replication factor C complex (RFC) subunits. The last function, in turn, triggers post-UV checkpoint activation and… CONTINUE READING
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Pathways of mammalian replication fork restart

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