BRCA1 is a negative modulator of the PRC2 complex.

@article{Wang2013BRCA1IA,
  title={BRCA1 is a negative modulator of the PRC2 complex.},
  author={Lan Wang and Xianzhuo Zeng and Shuai Chen and Liya Ding and Jian Zhong and Jonathan C Zhao and Liguo Wang and Aaron Sarver and Antonius A Koller and Jizu Zhi and Yupo Ma and Jindan Yu and Junjie Chen and Haojie Huang},
  journal={The EMBO journal},
  year={2013},
  volume={32 11},
  pages={1584-97}
}
The Polycomb-repressive complex 2 (PRC2) is important for maintenance of stem cell pluripotency and suppression of cell differentiation by promoting histone H3 lysine 27 trimethylation (H3K27me3) and transcriptional repression of differentiation genes. Here we show that the tumour-suppressor protein BRCA1 interacts with the Polycomb protein EZH2 in mouse embryonic stem (ES) and human breast cancer cells. The BRCA1-binding region in EZH2 overlaps with the noncoding RNA (ncRNA)-binding domain… CONTINUE READING