BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation‐induced gene activation of p21 or Mdm2

@article{Hill2004BRCA1IW,
  title={BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation‐induced gene activation of p21 or Mdm2},
  author={David A. Hill and Ivana L. de la Serna and Timothy M Veal and Anthony N. Imbalzano},
  journal={Journal of Cellular Biochemistry},
  year={2004},
  volume={91}
}
BRCA1 is a tumor suppressor gene linked to familial breast and ovarian cancer. The BRCA1 protein has been implicated in a diverse set of cellular functions, including activation of gene expression by the p53 tumor suppressor and control of homologous recombination (HR) during DNA repair. Prior reports have demonstrated that BRCA1 can exist in cells in a complex with the BRG1‐based SWI/SNF ATP‐dependent chromatin remodeling enzymes and that SWI/SNF components contribute to p53‐mediated gene… 
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TLDR
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