BRCA1 interacts with FHL2 and enhances FHL2 transactivation function

@article{Yan2003BRCA1IW,
  title={BRCA1 interacts with FHL2 and enhances FHL2 transactivation function},
  author={Jing-hua Yan and Jianhua Zhu and Hong-jun Zhong and Qiu-jun Lu and Cui-fen Huang and Qinong Ye},
  journal={FEBS Letters},
  year={2003},
  volume={553}
}
Germ‐line mutations in BRCA1 are associated with an increased lifetime risk of developing breast and/or ovarian tumors. The BRCA1 gene product is a 220‐kDa protein that contains a tandem of two BRCA1 C‐terminal (BRCT) domains required for transcription. In an attempt to understand how BRCA1 exerts its function through BRCT domains, we search for partners of the BRCT domains of BRCA1. Using the yeast two‐hybrid system, we identified the four and a half LIM‐only protein 2 (FHL2) as a novel BRCA1… 
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