BRCA1-hapoinsufficiency: Unraveling the molecular and cellular basis for tissue-specific cancer.

Abstract

Over the past 20 years tremendous progress has been made in understanding the function of BRCA1 gene products. Yet one question still remains: why is mutation of BRCA1 typically associated with preferential development of breast and ovarian cancers and not tumors in other tissues? Here we discuss recent evidence documenting the effect of BRCA1… (More)
DOI: 10.1080/15384101.2016.1141841

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