BRCA1 gene promoter methylation status in high-grade serous ovarian cancer patients--a study of the tumour Bank ovarian cancer (TOC) and ovarian cancer diagnosis consortium (OVCAD).

@article{Ruscito2014BRCA1GP,
  title={BRCA1 gene promoter methylation status in high-grade serous ovarian cancer patients--a study of the tumour Bank ovarian cancer (TOC) and ovarian cancer diagnosis consortium (OVCAD).},
  author={Ilary Ruscito and Desislava Dimitrova and I Monteiro Vasconcelos and Katharina Gellhaus and Tim Schwachula and Filippo Bellati and Robert Zeillinger and Pierluigi Benedetti-Panici and Ignace Vergote and Sven Mahner and D Cacsire-Tong and Nicole Concin and Silvia Darb-Esfahani and Sandrijne Lambrechts and Jalid Sehouli and Sven Olek and Elena Ioana Braicu},
  journal={European journal of cancer},
  year={2014},
  volume={50 12},
  pages={2090-8}
}
BACKGROUND Mutations in BRCA1/2 genes are involved in the pathogenesis of breast and ovarian cancer. Inactivation of these genes can also be mediated by hypermethylation of CpGs in the promoter regions. Aim of this study was to analyse the clinical impact of BRCA1 promoter gene methylation status in a homogenous cohort of high-grade serous ovarian cancer (HGSOC) patients. METHODS The cohort included 257 primary HGSOC patients treated by cytoreduction and platinum-based chemotherapy. DNA was… CONTINUE READING