BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis.

@article{Quinn2003BRCA1FA,
  title={BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis.},
  author={Jennifer E. Quinn and Richard D. Kennedy and Paul Mullan and Paula M. Gilmore and Michael P. Carty and Patrick Gerard Johnston and Denis Paul Harkin},
  journal={Cancer research},
  year={2003},
  volume={63 19},
  pages={6221-8}
}
We have evaluated the role played by BRCA1 in mediating the phenotypic response to a range of chemotherapeutic agents commonly used in cancer treatment. Here we provide evidence that BRCA1 functions as a differential mediator of chemotherapy-induced apoptosis. Specifically, we demonstrate that BRCA1 mediates sensitivity to apoptosis induced by antimicrotubule agents but conversely induces resistance to DNA-damaging agents. These data are supported by a variety of experimental models including… CONTINUE READING

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