BRCA1 founder mutations and ovarian cancer in Belarus

Abstract

In Belarus and other Slavic countries, founder mutations in the BRCA1 gene are responsible for a significant proportion of breast cancer cases. BRCA1 mutations also predispose to ovarian cancer. The aim of this study was to estimate the frequency of the three BRCA1 founder mutations in Belarus. The study group consisted of 134 consecutive, newly diagnosed… (More)

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