BRCA1 dysfunction in sporadic basal-like breast cancer

@article{Turner2007BRCA1DI,
  title={BRCA1 dysfunction in sporadic basal-like breast cancer},
  author={Nicholas C. Turner and Jorge S Reis-Filho and Anna Marie Russell and Robert Springall and Kenneth F. Ryder and Dawn Steele and Kay Savage and Cheryl E. Gillett and F Schmitt and Alan Ashworth and Andrew N. J. Tutt},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={2126-2132}
}
Basal-like breast cancers form a distinct subtype of breast cancer characterized by the expression of markers expressed in normal basal/myoepithelial cells. Breast cancers arising in carriers of germline BRCA1 mutations are predominately of basal-like type, suggesting that BRCA1 dysfunction may play a role in the pathogenesis of sporadic basal-like cancers. We analysed 37 sporadic breast cancers expressing the basal marker cytokeratin 5/6, and age- and grade-matched controls, for downregulation… CONTINUE READING
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