BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene

@article{Snouwaert1999BRCA1DE,
  title={BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene},
  author={John N. Snouwaert and Lori C. Gowen and Anne M. Latour and Amy R. Mohn and Andrew T Xiao and Lauren DiBiase and Beverly H. Koller},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={7900-7907}
}
BRCA1 is a nuclear phosphoprotein that has been classified as a tumor suppressor based on the fact that women carrying a mutated copy of the BRCA1 gene are at increased risk of developing breast and ovarian cancer. The association of BRCA1 with RAD51 has led to the hypothesis that BRCA1 is involved in DNA repair. We describe here the generation and analysis… CONTINUE READING