BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability.


Germline mutations in BRCA1 predispose carriers to a high incidence of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through critical roles in DNA repair, cell-cycle arrest, and transcriptional control. A major question has been why BRCA1 loss or mutation leads to tumors mainly in estrogen-regulated tissues, given that BRCA1 has… (More)
DOI: 10.1158/0008-5472.CAN-13-2611


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