BRCA1 and Oxidative Stress

  title={BRCA1 and Oxidative Stress},
  author={Yong Weon Yi and Hyo Jin Kang and Insoo Bae},
The breast cancer susceptibility gene 1 (BRCA1) has been well established as a tumor suppressor and functions primarily by maintaining genome integrity. Genome stability is compromised when cells are exposed to oxidative stress. Increasing evidence suggests that BRCA1 regulates oxidative stress and this may be another mechanism in preventing carcinogenesis in normal cells. Oxidative stress caused by reactive oxygen species (ROS) is implicated in carcinogenesis and is used strategically to treat… CONTINUE READING


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