BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity},
  author={Eliana Mc Tacconi and Xianning Lai and Cecilia Folio and Manuela Porru and Gijs Zonderland and Sophie Badie and Johanna Michl and Irene Sechi and M{\'e}lanie Rogier and Ver{\'o}nica Mat{\'i}a Garc{\'i}a and Ankita Sati Batra and Oscar M. Rueda and Peter Bouwman and Jos Jonkers and Anderson Joseph AstraZeneca R D Alderley Ryan and Bernardo Reina-San-Martin and Joannie Hui and Nelson SL Tang and Alejandra Bruna and Annamaria Biroccio and Madalena Tarsounas},
  booktitle={EMBO molecular medicine},
Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly toxic to cells and mice lacking the FA protein FANCD2. Here, we investigate whether HR-compromised cells are sensitive to acetaldehyde, similarly to FANCD2-deficient cells. We demonstrate that inactivation of HR factors BRCA1, BRCA2, or RAD51… CONTINUE READING
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