BRCA1- and BRCA2-related mutations: therapeutic implications in ovarian cancer.

@article{Pothuri2013BRCA1AB,
  title={BRCA1- and BRCA2-related mutations: therapeutic implications in ovarian cancer.},
  author={Bhavana Pothuri},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2013},
  volume={24 Suppl 8},
  pages={viii22-viii27}
}
Ovarian cancer is the deadliest among gynecologic cancers. Hereditary cancer related to BRCA1/2 gene mutations account for ~10%-12% of ovarian cancers. The BRCA1/2 proteins are important in homologous recombination (HR) repair of DNA. Patients with BRCA1/2 mutations have been reported to have improved chemosensitivity to platinum agents, longer disease-free intervals, and longer survivals than nonhereditary counterparts. Recent interest in poly(ADP-ribosyl) polymerase (PARP) proteins which are… CONTINUE READING