BRCA1 and BRCA2 mutations correlate with TP53 abnormalities and presence of immune cell infiltrates in ovarian high-grade serous carcinoma

@article{Mcalpine2012BRCA1AB,
  title={BRCA1 and BRCA2 mutations correlate with TP53 abnormalities and presence of immune cell infiltrates in ovarian high-grade serous carcinoma},
  author={Jessica N Mcalpine and H Christian Porter and Martin K{\"o}bel and Brad H. Nelson and Leah M Prentice and Steve E Kalloger and Janine Senz and Katy Milne and Jiarui Ding and Sohrab P. Shah and David G. Huntsman and C. Blake Gilks},
  journal={Modern Pathology},
  year={2012},
  volume={25},
  pages={740-750}
}
We characterized BRCA1 and BRCA2 status (mutation/methylation) in a consecutive series of cases of ovarian carcinoma in order to identify differences in clinicopathological features, molecular characteristics, and outcome between the pelvic high-grade serous cancers with (i) germline or somatic mutations in BRCA1 or BRCA2, (ii) methylation of BRCA1, and (iii) normal BRCA1 or BRCA2. In all, 131 women were identified prospectively, who were undergoing surgical staging and agreed to germline… CONTINUE READING