BRCA1 and BRCA2 mutations among familial breast cancer patients from Costa Rica

@article{GutirrezEspeleta2012BRCA1AB,
  title={BRCA1 and BRCA2 mutations among familial breast cancer patients from Costa Rica},
  author={G A Guti{\'e}rrez Espeleta and Marcia Llacuachaqui and Laura Garc{\'i}a-Jim{\'e}nez and M Aguilar Herrera and Kenneth Lo{\'a}iciga Vega and A. Ortiz and Robert Royer and S Li and Steven A. Narod},
  journal={Clinical Genetics},
  year={2012},
  volume={82}
}
Gutiérrez Espeleta GA, Llacuachaqui M, García‐Jiménez L, Aguilar Herrera M, Loáiciga Vega K, Ortiz A, Royer R, Li S, Narod SA. BRCA1 and BRCA2 mutations among familial breast cancer patients from Costa Rica. 
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Epidemiología descriptiva y genética molecular del cáncer de mama hereditario en Costa Rica
TLDR
It is found that the average age of women who carry a mutation is lower than in non-carrier women, and the increased incidence of breast cancer in recent years in Costa Rica should promote an increase in prevention policies and the establishment of efficient detection methods that allow early disease diagnosis.
[Descriptive epidemiology and molecular genetics of hereditary breast cancer in Costa Rica].
TLDR
It is found that the average age of women who carry a mutation is lower than in non-carrier women and the increased incidence of breast cancer in recent years in Costa Rica should promote an increase in prevention policies and the establishment of efficient detection methods that allow early disease diagnosis.
A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer
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This review affords quick access to the most frequent alterations among various populations which could be helpful in BRCA screening programs.
Frecuencia de las mutaciones en los genes BRCA en mujeres con agregación familiar de cáncer de glándula mamaria/ovario
TLDR
The review reveals that the family MGC and OC is twice as common compared with cases of the same disease of a sporadic origin, and this type of molecular studies allows other people who have family history of M GC and OC to perform early analysis and tests to prevent the future development of this neoplasia.
Study of BRCA2 Gene Mutations in EgyptianFemales with Breast Cancer
TLDR
It was apparent from the study findings that women with a strong family history were still at higher risk for developing the disease.
Hereditary cancer syndromes in Latino populations: genetic characterization and surveillance guidelines
TLDR
The genetic basis, phenotype characteristics, and the National Comprehensive Cancer Network’s screening, testing, and surveillance guidelines for the leading hereditary cancer syndromes are summarized to promote a better understanding of cancer genetics and genetic testing in Hispanic patients.
The spectrum of BRCA1 and BRCA2 alleles in Latin America and the Caribbean: a clinical perspective
Hereditary cancer predisposition gene testing allows the identification of individuals at high risk of cancer that may benefit from increased surveillance, chemoprevention, and prophylactic surgery.…
Prevalence and impact of founder mutations in hereditary breast cancer in Latin America
TLDR
Current data available on founder mutations described in the most common breast cancer predisposition genes: BRCA1, BRCa2 and TP53 are described.
Etiology of breast cancer ( C 50 ) in Central and South America
TLDR
This section briefly describes factors of breast cancer that are modifiable and could guide efforts for prevention in the Central and South American region.
Mutations in BRCA1, BRCA2 and other breast and ovarian cancer susceptibility genes in Central and South American populations
TLDR
A comprehensive review of 47 studies from 12 countries in Central and South America published between 2002 and 2017 reporting the prevalence and/or spectrum of mutations and pathogenic variants in BRCA1/2 and other BC susceptibility genes is conducted.
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References

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TLDR
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TLDR
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