BRCA1 and BRCA2 mutations across race and ethnicity: distribution and clinical implications.

@article{Kurian2010BRCA1AB,
  title={BRCA1 and BRCA2 mutations across race and ethnicity: distribution and clinical implications.},
  author={Allison W. Kurian},
  journal={Current opinion in obstetrics & gynecology},
  year={2010},
  volume={22 1},
  pages={72-8}
}
PURPOSE OF REVIEW To summarize evidence on the prevalence and spectrum of BRCA1 and BRCA2 BRCA1/2 mutations across racial and ethnic groups and discuss implications for clinical practice. RECENT FINDINGS The prevalence of BRCA1/2 mutations is comparable among breast cancer patients of African, Asian, white, and Hispanic descent: approximately 1-4% per gene. Among ovarian cancer patients in North America, BRCA1/2 mutations are present in 13-15%. Between racial/ethnic groups, there are… CONTINUE READING

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