BRCA1 and BRCA2: from molecular genetics to clinical medicine.

  title={BRCA1 and BRCA2: from molecular genetics to clinical medicine.},
  author={M. Anne Blackwood and Barbara L. Weber},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={16 5},
Inherited susceptibility to breast cancer has been an area of intense investigation for the past 10 years. Early work focused on identifying modes of transmission, which culminated in the identification of chromosome 17q12-21 as the first human genomic region that harbored an autosomal dominant susceptibility gene for breast cancer (BRCA1) in 1990. BRCA1 was subsequently identified and was followed shortly by the identification of BRCA2. Research in the past 3 years has elucidated much about… CONTINUE READING
51 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 51 extracted citations

Similar Papers

Loading similar papers…