BRCA1 and BRCA2: 1994 and beyond

@article{Narod2004BRCA1AB,
  title={BRCA1 and BRCA2: 1994 and beyond},
  author={Steven A. Narod and William D. Foulkes},
  journal={Nature Reviews Cancer},
  year={2004},
  volume={4},
  pages={665-676}
}
The discovery of the first gene associated with hereditary breast cancer, BRCA1, was anticipated to greatly increase our understanding of both hereditary and sporadic forms of breast cancer, and to lead to therapeutic and preventive breakthroughs. Much has been learned during the past decade about the genetic epidemiology of breast cancer, the ethnic distribution and clinical consequences of BRCA1 and BRCA2 mutations, and the central role of DNA repair in breast cancer susceptibility. The… 
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TLDR
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TLDR
Loss or mutation of BRCA1 or BRCa2 results in widespread genomic instability that is strikingly similar to the genomic instability found in the inherited disease Fanconi anemia.
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TLDR
The current understanding suggests that the molecular functions mediated by the terminal ends of BRCA1, which include an E3 ubiquitin ligase activity at the N-terminus and a protein-protein interaction surface at the C-terminal, are critical to the function of this protein in the response to DNA damage.
[Molecular basis of breast cancer related to BRCA 1 and BRCA2 genes: characteristics and targeting therapy].
TLDR
Successful treatment of mutation carrier's tumors is most likely to be achieved through cooperation of a pathologist, oncologist and a genetic laboratory performing BRCA genes mutation screening.
Prevalence of BRCA1 and BRCA2 mutations in Ashkenazi Jewish families with breast and pancreatic cancer
TLDR
Germline mutations in the BRCA2 cancer susceptibility gene are associated with an increased risk of pancreatic cancer (PC) and the influence of a family history of PC on BRCa mutation prevalence in patients with breast cancer (BC) is unknown.
Reviewing the characteristics of BRCA and PALB2-related cancers in the precision medicine era
Abstract Germline mutations in BRCA1 and BRCA2 (BRCA) genes confer high risk of developing cancer, especially breast and ovarian tumors. Since the cloning of these tumor suppressor genes over two
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