BRCA1 accelerates CtIP-mediated DNA-end resection.

@article{CruzGarca2014BRCA1AC,
  title={BRCA1 accelerates CtIP-mediated DNA-end resection.},
  author={Andr{\'e}s Cruz-Garc{\'i}a and Ana L{\'o}pez-Saavedra and Pablo Huertas},
  journal={Cell reports},
  year={2014},
  volume={9 2},
  pages={
          451-9
        }
}
DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In higher eukaryotes, CtIP regulates resection by integrating cellular signals via its posttranslational modifications and protein-protein interactions, including cell-cycle-controlled interaction with BRCA1. The role of BRCA1 in DNA-end resection is not clear. Here, we develop an assay to study DNA resection in higher eukaryotes at high resolution. We demonstrate that the BRCA1… CONTINUE READING

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