BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

@inproceedings{Hatchi2015BRCA1RT,
  title={BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair},
  author={Elodie Hatchi and Konstantina Skourti-Stathaki and Steffen Ventz and Luca Pinello and Angela Yen and Kinga Kamieniarz-Gdula and Stoil D. Dimitrov and Shailja Pathania and Kristine M. McKinney and Matthew L. Eaton and Manolis Kellis and Sarah J. Hill and Giovanni Parmigiani and Nicholas Proudfoot and David M. Livingston},
  booktitle={Molecular cell},
  year={2015}
}
The mechanisms contributing to transcription-associated genomic instability are both complex and incompletely understood. Although R-loops are normal transcriptional intermediates, they are also associated with genomic instability. Here, we show that BRCA1 is recruited to R-loops that form normally over a subset of transcription termination regions. There it mediates the recruitment of a specific, physiological binding partner, senataxin (SETX). Disruption of this complex led to R-loop-driven… CONTINUE READING
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