BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions.

@article{Brzovic2001BRCA1RD,
  title={BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions.},
  author={Peter S. Brzovic and J E Meza and Megan C King and Rachel E. Klevit},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 44},
  pages={41399-406}
}
Cancer-predisposing missense mutations in the RING domain of BRCA1 primarily target Zn(2+)-liganding residues. Here we report on the structural consequences of such mutations introduced into the second Zn(2+) site (Site II) of the BRCA1 RING domain and their effect on the interaction with the BARD1 RING domain. Each of the BRCA1 Site II mutants still interact and form a stable heterodimer with BARD1. Limited proteolysis of BRCA1/BARD1 complexes, monitored by matrix-assisted laser desorption… CONTINUE READING

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