BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease

  title={BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease},
  author={Teresa A. Evans and Arun K. Raina and Andr{\'e} Delacourte and Olga N Aprelikova and Hyoung-Gon Lee and Xiongwei Zhu and George Perry and Mark A. Smith},
  journal={International Journal of Medical Sciences},
  pages={140 - 145}
In Alzheimer disease, neuronal degeneration and the presence of neurofibrillary tangles correlate with the severity of cognitive decline. Neurofibrillary tangles contain the antigenic profile of many cell cycle markers, reflecting a re-entry into the cell cycle by affected neurons. However, while such a cell cycle re-entry phenotype is an early and consistent feature of Alzheimer disease, the mechanisms responsible for neuronal cell cycle are unclear. In this regard, given that a dysregulated… CONTINUE READING


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