BRCA1 185delAG mutant protein, BRAt, up-regulates maspin in ovarian epithelial cells.

Abstract

OBJECTIVE Aggressive clinical course and difficult detection of ovarian cancer are major challenges to improving patient survival and necessitate avid investigation into more effective therapeutic approaches. Understanding early molecular and pathological changes in high risk patients, such as BRCA1 mutation carriers, can provide candidates for molecular… (More)
DOI: 10.1016/j.ygyno.2009.10.052

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