BRCA1: A Novel Prognostic Factor in Resected Non-Small-Cell Lung Cancer

@article{Rosell2007BRCA1AN,
  title={BRCA1: A Novel Prognostic Factor in Resected Non-Small-Cell Lung Cancer},
  author={Rafael Rosell and Marcin Skrzypski and Ewa Jassem and M{\`i}quel Taron and Roberta Bartolucci and Jos{\'e} Javier S{\'a}nchez and Pedro E M{\'e}ndez and Imane Chaib and Laia Perez-Roca and Amelia Szymanowska and Witold Rzyman and Francesco Di Puma and Grażyna Kobierska-Gulida and Raffaele Farabi and Jacek Jassem},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={581 - 592}
}
BACKGROUND Although early-stage non-small-cell lung cancer (NSCLC) is considered a potentially curable disease following complete resection, patients have a wide spectrum of survival according to stage (IB, II, IIIA). Within each stage, gene expression profiles can identify patients with a higher risk of recurrence. We hypothesized that altered mRNA expression in nine genes could help to predict disease outcome: excision repair cross-complementing 1 (ERCC1), myeloid zinc finger 1 (MZF1) and… CONTINUE READING

5 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Although early - stage non - small - cell lung cancer ( NSCLC ) is considered a potentially curable disease following complete resection , patients have a wide spectrum of survival according to stage ( IB , II , IIIA ) .
Although early - stage non - small - cell lung cancer ( NSCLC ) is considered a potentially curable disease following complete resection , patients have a wide spectrum of survival according to stage ( IB , II , IIIA ) .
We performed real - time quantitative polymerase chain reaction ( RT - QPCR ) in frozen lung cancer tissue specimens from 126 chemonaive NSCLC patients who had undergone surgical resection and evaluated the association between gene expression levels and survival .
Although early - stage non - small - cell lung cancer ( NSCLC ) is considered a potentially curable disease following complete resection , patients have a wide spectrum of survival according to stage ( IB , II , IIIA ) .
We performed real - time quantitative polymerase chain reaction ( RT - QPCR ) in frozen lung cancer tissue specimens from 126 chemonaive NSCLC patients who had undergone surgical resection and evaluated the association between gene expression levels and survival .
Although early - stage non - small - cell lung cancer ( NSCLC ) is considered a potentially curable disease following complete resection , patients have a wide spectrum of survival according to stage ( IB , II , IIIA ) .
Although early - stage non - small - cell lung cancer ( NSCLC ) is considered a potentially curable disease following complete resection , patients have a wide spectrum of survival according to stage ( IB , II , IIIA ) .
Although early - stage non - small - cell lung cancer ( NSCLC ) is considered a potentially curable disease following complete resection , patients have a wide spectrum of survival according to stage ( IB , II , IIIA ) .
We performed real - time quantitative polymerase chain reaction ( RT - QPCR ) in frozen lung cancer tissue specimens from 126 chemonaive NSCLC patients who had undergone surgical resection and evaluated the association between gene expression levels and survival .
We hypothesized that altered mRNA expression in nine genes could help to predict disease outcome : excision repair cross - complementing 1 ( ERCC1 ) , myeloid zinc finger 1 ( MZF1 ) and Twist1 ( which regulate N - cadherin expression ) , ribonucleotide reductase subunit M1 ( RRM1 ) , thioredoxin-1 ( TRX1 ) , tyrosyl - DNA phosphodiesterase ( Tdp1 ) , nuclear factor of activated T cells ( NFAT ) , BRCA1 , and the human homolog of yeast budding uninhibited by benzimidazole ( BubR1 ) .
All Topics