BRCA1/2 germline mutations in Jewish patients with uterine serous carcinoma.

@article{Bruchim2010BRCA12GM,
  title={BRCA1/2 germline mutations in Jewish patients with uterine serous carcinoma.},
  author={Ilan Bruchim and Keren Amichay and Dvora Kidron and Zohar Attias and Tal Biron-Shental and Liat Drucker and Eitan Friedman and Haim Werner and Ami Fishman},
  journal={International journal of gynecological cancer : official journal of the International Gynecological Cancer Society},
  year={2010},
  volume={20 7},
  pages={
          1148-53
        }
}
INTRODUCTION Whether and to what extent germline mutations in the BRCA1 and BRCA2 genes increase the risk for developing uterine serous carcinoma (USC) remain controversial. We assessed the rate of the 3 predominant BRCA1/2 mutations in Jewish patients with USC and the relevance of carrier status to clinicopathological features and survival. METHODS Jewish patients with histologically confirmed USC diagnosed between April 1997 and December 2007 were genotyped for the 3 predominant BRCA1… CONTINUE READING

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