BRCA1, BRCA2, and hereditary nonpolyposis colorectal cancer gene mutations in an unselected ovarian cancer population: relationship to family history and implications for genetic testing.

@article{Rubin1998BRCA1BA,
  title={BRCA1, BRCA2, and hereditary nonpolyposis colorectal cancer gene mutations in an unselected ovarian cancer population: relationship to family history and implications for genetic testing.},
  author={Stephen C. Rubin and M. Anne Blackwood and Christina A. Bandera and Kian Behbakht and Ivor Benjamin and Timothy R. Rebbeck and Jeff Boyd},
  journal={American journal of obstetrics and gynecology},
  year={1998},
  volume={178 4},
  pages={670-7}
}
OBJECTIVE Our purpose was to determine the prevalence of BRCA1, BRCA2, and hereditary nonpolyposis colorectal cancer gene mutations in a large, unselected population of ovarian cancer patients and to evaluate the relationship between mutation status and a routinely obtained family history of cancer. STUDY DESIGN One hundred sixteen consecutive ovarian cancer patients seen for routine clinical care were examined for BRCA1, BRCA2, hMSH2, and hMLH1 gene mutations with use of the polymerase chain… CONTINUE READING