BRCA-associated breast cancer: absence of a characteristic immunophenotype.

  title={BRCA-associated breast cancer: absence of a characteristic immunophenotype.},
  author={Mark E. Robson and P. Sreeranga Rajan and Paul Peter Rosen and Theresa Gilewski and Y Hirschaut and Peter I. Pressman and B. A. Haas and Larry Norton and Kenneth Offit},
  journal={Cancer research},
  volume={58 9},
To characterize the biological features of breast cancer associated with germ-line mutations in BRCA1 and BRCA2, invasive tumors were studied from 58 Jewish women ascertained through studies of early-onset breast cancer. All women were tested for the BRCA1 founder mutations 187delAG (commonly known as 185delAG) and 5385insC (commonly known as 5382insC) and the BRCA2 founder mutation 6174delT. Mutations were detected in 17 of 58 (29.3%) women. Comparing BRCA-associated breast cancers (BABCs) to… CONTINUE READING